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101.
Graphene field-effect transistors (GFET) have emerged as powerful detection platforms enabled by the advent of chemical vapor deposition (CVD) production of the unique atomically thin 2D material on a large scale. DNA aptamers, short target-specific oligonucleotides, are excellent sensor moieties for GFETs due to their strong affinity to graphene, relatively short chain-length, selectivity, and a high degree of analyte variability. However, the interaction between DNA and graphene is not fully understood, leading to questions about the structure of surface-bound DNA, including the morphology of DNA nanostructures and the nature of the electronic response seen from analyte binding. This review critically evaluates recent insights into the nature of the DNA graphene interaction and its affect on sensor viability for DNA, small molecules, and proteins with respect to previously established sensing methods. We first discuss the sorption of DNA to graphene to introduce the interactions and forces acting in DNA based GFET devices and how these forces can potentially affect the performance of increasingly popular DNA aptamers and even future DNA nanostructures as sensor substrates. Next, we discuss the novel use of GFETs to detect DNA and the underlying electronic phenomena that are typically used as benchmarks for characterizing the analyte response of these devices. Finally, we address the use of DNA aptamers to increase the selectivity of GFET sensors for small molecules and proteins and compare them with other, state of the art, detection methods. 相似文献
102.
103.
高效液相色谱-同位素稀释质谱法定量分析人生长激素 总被引:1,自引:0,他引:1
建立了人生长激素( hGH)纯化分析和高效液相色谱( HPLC)与同位素稀释质谱( IDMS)联用高准确度绝对定量方法。采用快速蛋白液相色谱来分离纯化hGH,以傅里叶变换离子回旋共振质谱仪( FTICR-MS)准确地测定蛋白质的分子质量。纯化的hGH经酸水解后,采用KINETEX C18色谱柱为分析柱,以水(含0.1%三氟乙酸)和乙腈为流动相,等梯度分离,流速0.2 mL/min,温度40℃,采用电喷雾正离子模式进行电离,选择多反应监测模式进行检测,内标法定量分析。结果表明,FTICR-MS所测得的分子量实测值与理论值仅相差0.31 Da,脯氨酸、缬氨酸和苯丙氨酸在液相条件下5 min内达到基线分离,在最优条件下,hGH含量测定结果为186.80 mg/g,相对标准偏差为0.52%。利用本方法参加国际比对,比对结果与参考值等效一致。本方法具有简易、实用的特点,并且准确可靠,可作为hGH纯品标准物质的定值方法,为hGH的日常检测提供参考。 相似文献
104.
Dr. Georgian Melinte Dr. Veselina Georgieva Dr. Marie‐Anne Springuel‐Huet Dr. Andreï Nossov Prof. Ovidiu Ersen Dr. Flavien Guenneau Prof. Antoine Gedeon Dr. Ana Palčić Dr. Krassimir N. Bozhilov Dr. Cuong Pham‐Huu Prof. Shilun Qiu Dr. Svetlana Mintova Dr. Valentin Valtchev 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(50):18316-18327
The principle aspects and constraints of the dynamics and kinetics of zeolite nucleation in hydrogel systems are analyzed on the basis of a model Na‐rich aluminosilicate system. A detailed time‐series EMT‐type zeolite crystallization study in the model hydrogel system was performed to elucidate the topological and temporal aspects of zeolite nucleation. A comprehensive set of analytical tools and methods was employed to analyze the gel evolution and complement the primary methods of transmission electron microscopy (TEM) and nuclear magnetic resonance (NMR) spectroscopy. TEM tomography reveals that the initial gel particles exhibit a core–shell structure. Zeolite nucleation is topologically limited to this shell structure and the kinetics of nucleation is controlled by the shell integrity. The induction period extends to the moment when the shell is consumed and the bulk solution can react with the core of the gel particles. These new findings, in particular the importance of the gel particle shell in zeolite nucleation, can be used to control the growth process and properties of zeolites formed in hydrogels. 相似文献
105.
Using cheap n‐butylamine as template, ZSM‐5 zeolites have been successfully synthesized and coated on monolithic interconnected macroporous Al2O3 by the secondary growth method. The use of cheap n‐butylamine could significantly reduce the synthesis cost. Hierarchical monolithic ZSM‐5 zeolites were prepared from synthetic mixtures with different H2O/Na2O or SiO2/Al2O3 ratio. The synthesized samples were characterized by scanning electron microscopy (SEM), X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FT‐IR) and N2 adsorption‐desorption. The results show that the hierarchical monolithic zeolites were obtained with cheap n‐butylamine template as template. During the hydrothermal reaction process, the morphology of the micrometer‐sized support was well maintained. The irregular crystals were formed in a wide range of the H2O/Na2O or SiO2/Al2O3 ratio of synthetic mixtures and coated on monolithic Al2O3. The relative crystallinity of the zeolites was highest at H2O/Na2O=250 or SiO2/Al2O3=160. This type of composites exhibited hierarchical porous structures and relatively high specific surface areas. 相似文献
106.
通过缓慢滴加焦磷酸钾的硝酸溶液到钼酸铵溶液中制得了大颗粒磷钼酸铵(AMP)。研究了AMP的成核速率(G)与晶体生长速率。与晶体生长速率相比成核速率的反应级数更高。最初,大颗粒磷钼酸铵的结晶过程处于相变反应控制的动力学区域,此时溶液的过饱和生成速率比过饱和消除速率高。晶体线生长速率与溶液的过饱和度先增加后降低。在滴加中期,过饱和消除速率增长到与其生成速率相当。在滴加后期,晶体成核速率快速增高,而晶体的线生长速率下降。晶体的成核速率成为过饱和消除的唯一控制步骤。因此,AMP成核大部分是在首先接触到滴加液的局部溶液中完成的。 相似文献
107.
Dr. Łukasz Dobrzycki Paulina Taraszewska Prof. Dr. Roland Boese Prof. Dr. Michał K. Cyrański Dr. Sebastian A. Cirkel 《Angewandte Chemie (International ed. in English)》2015,54(35):10138-10144
The dilution of tert‐butylamine (tBA) with water and subsequent cooling leads to a large series of different crystalline hydrates by an in situ IR laser melting‐zone procedure. The crystal structures were determined for tBA?n H2O, with n=0, , 1, 7 , 7 , 9 , 11, and 17. For the two lower hydrates (n= , 1), one‐ and two‐dimensional hydrogen‐bonded networks are formed, respectively. The higher hydrates (n>1) exhibit a clathrate‐like three‐dimensional water framework with the tBA molecules as part of, or sitting inside, the cages. In all cases, tBA is hydrogen‐bonded to the H2O framework. In the intermediate range (1相似文献
108.
Nicholas P. Calta Dr. Jino Im Alexandra P. Rodriguez Dr. Lei Fang Dr. Daniel E. Bugaris Dr. Thomas C. Chasapis Prof. Arthur J. Freeman Prof. Mercouri G. Kanatzidis 《Angewandte Chemie (International ed. in English)》2015,54(32):9186-9191
EuIr4In2Ge4 is a new intermetallic semiconductor that adopts a non‐centrosymmetric structure in the tetragonal ${I\bar 42m}$ space group with unit cell parameters a=6.9016(5) Å and c=8.7153(9) Å. The compound features an indirect optical band gap Eg=0.26(2) eV, and electronic‐structure calculations show that the energy gap originates primarily from hybridization of the Ir 5d orbitals, with small contributions from the Ge 4p and In 5p orbitals. The strong spin–orbit coupling arising from the Ir atoms, and the lack of inversion symmetry leads to significant spin splitting, which is described by the Dresselhaus term, at both the conduction‐ and valence‐band edges. The magnetic Eu2+ ions present in the structure, which do not play a role in gap formation, order antiferromagnetically at 2.5 K. 相似文献
109.
A Family of Molecular Sieves Containing Framework‐Bound Organic Structure‐Directing Agents 下载免费PDF全文
Jun Kyu Lee Dr. Jiho Shin Nak Ho Ahn Alessandro Turrina Dr. Min Bum Park Dr. Youngchul Byun Prof. Sung June Cho Prof. Paul A. Wright Prof. Suk Bong Hong 《Angewandte Chemie (International ed. in English)》2015,54(38):11097-11101
Organic structure‐directing agents (OSDAs), such as quaternary ammonium cations and amines, used in the synthesis of zeolites and related crystalline microporous oxides usually end up entrapped inside the void spaces of the crystallized inorganic host lattice. But none of them is known to form direct chemical bonds to the framework of these industrially important catalysts and adsorbents. We demonstrate that ECR‐40, currently regarded as a typical silicoaluminophosphate molecular sieve, constitutes instead a new family of inorganic‐organic hybrid networks in which the OSDAs are covalently bonded to the inorganic framework. ECR‐40 crystallization begins with the formation of an Al–OSDA complex in the liquid phase in which the Al is octahedrally coordinated. This unit is incorporated in the crystallizing ECR‐40. Subsequent removal of framework‐bound OSDAs generates Al‐O‐Al linkages in a fully tetrahedrally coordinated framework. 相似文献
110.
Chain‐Growth Click Polymerization of AB2 Monomers for the Formation of Hyperbranched Polymers with Low Polydispersities in a One‐Pot Process 下载免费PDF全文
Yi Shi Robert W. Graff Xiaosong Cao Xiaofeng Wang Haifeng Gao 《Angewandte Chemie (International ed. in English)》2015,54(26):7631-7635
Hyperbranched polymers are important soft nanomaterials but robust synthetic methods with which the polymer structures can be easily controlled have rarely been reported. For the first time, we present a one‐pot one‐batch synthesis of polytriazole‐based hyperbranched polymers with both low polydispersity and a high degree of branching (DB) using a copper‐catalyzed azide–alkyne cycloaddition (CuAAC) polymerization. The use of a trifunctional AB2 monomer that contains one alkyne and two azide groups ensures that all Cu catalysts are bound to polytriazole polymers at low monomer conversion. Subsequent CuAAC polymerization displayed the features of a “living” chain‐growth mechanism with a linear increase in molecular weight with conversion and clean chain extension for repeated monomer additions. Furthermore, the triazole group in a linear (L) monomer unit complexed CuI, which catalyzed a faster reaction of the second azide group to quickly convert the L unit into a dendritic unit, producing hyperbranched polymers with DB=0.83. 相似文献